More Pages: Harper Page 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63


a slighly biased approach to John Brown

Biotech: Science and InvestingThe first half of the book presents the science of biotechnology at a level appropriate for the intelligent layperson. He explains the difference between biotech and traditional pharmaceuticals (large molecules often produced by the human body versus small molecules), describes the framework of disease (anatomy, physiology, pathology, and treatment), presents the various approaches to developing biotech drugs (e.g., gene therapy, monoclonal antibodies, antisense), and identifies specific types of disease which biotech products may treat (cardiovascular, neurological, metabolic, transplantation).
The second half presents factors to consider and strategies to employ in biotech investing. A biotech company's pipeline of potential future drugs is the most important factor in evaluating its investment potential. However, the value of each individual pipeline drug must be evaluated in terms of its progress through the process of clinical trials leading to approval and each drug must be assigned an appropriate weighting which increases as the drug progresses through these trials. Harper also presents his own formula for determining the value of biotech stocks which I have not seen elsewhere. It uses book value, share price, sales per share, and cash per share to estimate a stock's "financial valuation"; shares outstanding, average daily volume, institutional investment, and volatility (beta) to estimate "liquidity"; and present share price together with the 52-week high and low to represent "scope for growth". These three components are then combined to determine the overall valuation.
This approach appears to be heuristic rather than one grounded in classical financial valuation theory (as presented, for example, in Investment Valuation by Aswath Damodaran). Harper's approach may be particularly useful in valuing companies that are not currently profitable but would be more convincing if he provided either an explanation of how the formula was developed or historical data that justifies its use.
Harper concludes by applying his formula to evaluate the investment potential of numerous biotech companies as of the date of his writing. He stresses that this evaluation is only valid at that one point in time and will change with the rapidly changing technology and financial status of the companies.
Overall, Harper's book was interesting and very helpful in understanding the science of biotech. I would caution against using his approach to allocate a major percentage of any portfolio to biotech stocks (which Harper does not advocate). I don't mind an occasional small bet on a currently unprofitable company but prefer to invest primarily in companies (including some biotechs) with current and growing profits.
In addition to Damodaran's rather technical book cited above, a reader interested in this area might also consider Michael Murphy's Every Investor's Guide to High-Tech Stocks and Mutual Funds which covers biotech and other forms of technology from an investor's viewpoint.


Good review of Jackson Pollock's work, but not personal enou

Jane's World War II Aircraft by Jeffrey L EthellThere are specs for each. This book is divided by Country
Each aircraft has two pages and one photo. As it says on the
front of the book.....A mine of information. This is correct.
I am not an expert but only the common aircraft for each country
are in the book. This is a great book for eight bucks. It is
a pocket book.....since it fits in your pocket! This is good for a first reference. If you need more info there are other books/the Internet/the public Library.


Romantic

Why didn't I consider that?

An excellent look inside a young lady's mind!

Great book, but ONE Major Mistake

MAde you realize what these children really go through!